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General Toxicity

GENERAL TOXICITY

Acute Toxicity Studies

Acute Oral (OECD 420, OECD 423)
Acute Dermal (OECD 402)
Acute Inhalation (OECD 403)
Acute Dermal irritation/Corrosion (OECD 404)
Acute Eye Irritation/Corrosion (OECD 405)
Skin Sensitization (OECD 406/ OECD 442B)

2.Repeated dose Toxicity Studies in Rodents and Non-rodents

Sub-acute Toxicity -14 days DRF
Sub-acute 28 days Toxicity (OECD 407)
Sub-chronic 90 days Toxicity (OECD 408)
Sub-acute inhalation (OECD-412)- Will be conducted at partner site
Chronic Toxicity (180 and 360 days) (OECD 452)
Toxicokinetics

3. In Vitro Alternative Assays

In vitro skin corrosion (OECD TG 431)
In Vitro Skin Irritation (OECD TG 439)
Skin Sensitization (DPRA Assay, OECD TG 442C)
In Vitro Eye Irritation Test (OECD TG 492)